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1

Dietary cholesterol, fats and risk of Parkinson's disease in the Singapore Chinese Health Study

Tan, L. C., Methawasin, K., Tan, E.-K., Tan, J. H., Au, W.-L., Yuan, J.-M., Koh, W.-P.

Journal:

Journal of Neurology Neurosurgery & Psychiatry

Year:

2015

Language:

english

File:

PDF, 181 KB

english, 2015

2

Titin based viscosity in ventricular physiology: An integrative investigation of PEVK–actin interactions

Charles S. Chung, Methajit Methawasin, O. Lynne Nelson, Michael H. Radke, Carlos G. Hidalgo, Michael Gotthardt, Henk L. Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2011

Language:

english

File:

PDF, 910 KB

english, 2011

3

The multifunctional Ca2 +/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements

Carlos G. Hidalgo, Charles S. Chung, Chandra Saripalli, Mei Methawasin, Kirk R. Hutchinson, George Tsaprailis, Siegfried Labeit, Alicia Mattiazzi, Henk L. Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2013

Language:

english

File:

PDF, 977 KB

english, 2013

4

Mouse Intact and Skinned Cardiac Myocyte Mechanics: Crossbridge and Titin-Based Stress in Unactivated Cells

Methawasin, Methajit, King, Nicholas M.P., Nedrud, Joshua, Chung, Charles S., Helmes, Michiel, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 41 KB

english, 2011

5

Clinico-genetic comparisons of paroxysmal kinesigenic dyskinesia patients with and without PRRT2 mutations

Tan, L. C. S., Methawasin, K., Teng, E. W. L., Ng, A. R. J., Seah, S. H., Au, W. L., Liu, J. J., Foo, J. N., Zhao, Y., Tan, E. K.

Journal:

European Journal of Neurology

Year:

2014

Language:

english

File:

PDF, 452 KB

english, 2014

6

Titin-Based Passive Tension is Increased in a Titin AI KO Mouse

Slater, Rebecca, Hutchinson, Kirk, Methawasin, Mei, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 67 KB

english, 2014

7

Quantification of Titin Based Viscosity: Temperature, Lattice Compression and Integrative Physiology

Chung, Charles S., Methawasin, Methajit, Nelson, O. Lynne, Gotthardt, Michael, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 39 KB

english, 2011

8

Effect of Shortening Titin's Proximal IG Segment on Passive Cellular Mechanics

Methawasin, Methajit, Chung, Charles S., Nedrud, Joshua, Helmes, Michiel, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 39 KB

english, 2012

9

Shortening of Titin's Elastic Tandem Ig Segment Leads to Cardiac Hypertrophy and Diastolic Dysfunction

Chung, Charles S., Hutchinson, Kirk R., Methawasin, Mei, Saripalli, Chandra, Smith, John E., Hidalgo, Carlos G., Luo, Xiuju, Labeit, Siegfried, Guo, Caiying, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 46 KB

english, 2013

10

The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II Delta (CaMKIIδ) Phosphorylates Titin N2B and PEVK Spring Elements

Hidalgo, Carlos G., Methawasin, Mei, Chung, Charles S., Bogomolovas, Julius, Gash, Alexander, Labeit, Siegfried, Mattiazzi, Alicia, Granzier, Henk

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 39 KB

english, 2012

11

Importance of Titin Based Viscosity in Cardiac Function: an Integrative Study on PEVK-Actin Interactions

Chung, Charles S., Methawasin, Methajit, Popper, Joseph, Nelson, O. Lynne, Gotthardt, Michael, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 57 KB

english, 2010

12

Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism but has a Beneficial Effect on Diastole

Methawasin, Mei, Hutchinson, Kirk R., Lee, Eun-Jeong, Smith, John E., Saripalli, Chandra, Hidalgo, Carlos G., Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 221 KB

english, 2014

13

PO25-TH-09 Chorea-Ballism: various radiologic findings from various etiologies

Methawasin, K., Kaufman, L.

Journal:

Journal of the Neurological Sciences

Year:

2009

Language:

english

File:

PDF, 45 KB

english, 2009

14

A New Mouse Model in which the Proximal Tandem Ig Element of Titin is Truncated (IGKO) - Assessment of Diastolic Function

Chung, Charles S., Hutchinson, Kirk R., Methawasin, Methajit, Cromer, Nathan E., Luo, Xiuju, Guo, Caiying, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 38 KB

english, 2012

15

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

Granzier, Henk L., Hutchinson, Kirk R., Tonino, Paola, Methawasin, Mei, Li, Frank W., Slater, Rebecca E., Bull, Mathew M., Saripalli, Chandra, Pappas, Christopher T., Gregorio, Carol C., Smith, John E

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

16

Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats

Charoenphandhu, Narattaphol, Teerapornpuntakit, Jarinthorn, Methawasin, Methajit, Wongdee, Kannikar, Thongchote, Kanogwun, Krishnamra, Nateetip

Journal:

Canadian Journal of Physiology and Pharmacology

Year:

2008

Language:

english

File:

PDF, 392 KB

english, 2008

17

Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction

Chung, C. S., Hutchinson, K. R., Methawasin, M., Saripalli, C., Smith, J. E., Hidalgo, C. G., Luo, X., Labeit, S., Guo, C., Granzier, H. L.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.39 MB

english, 2013

18

Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells

King, N. M. P., Methawasin, M., Nedrud, J., Harrell, N., Chung, C. S., Helmes, M., Granzier, H.

Journal:

The Journal of General Physiology

Year:

2010

Language:

english

File:

PDF, 1.66 MB

english, 2010

19

Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole

Methawasin, M., Hutchinson, K. R., Lee, E.-J., Smith, J. E., Saripalli, C., Hidalgo, C. G., Ottenheijm, C. A. C., Granzier, H.

Journal:

Year:

2014

Language:

english

File:

PDF, 5.05 MB

english, 2014

20

Exercise Mitigates Increased Diastolic Stiffness in the Titin IA KO Mouse

Slater, Rebecca E., Methawasin, Mei, Strom, Josh, Saripalli, Chandra, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 46 KB

english, 2016

21

Upregulating Compliant Titin in the Heart Attenuates Left Ventricular Stiffness in a Mouse Model with Diastolic Dysfunction

Methawasin, Mei, Strom, Joshua G., Fernandez, Vanessa, Saripalli, Chandra, Smith, John E., Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 46 KB

english, 2016

22

Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin

Kolb, Justin, Li, Frank, Methawasin, Mei, Adler, Maya, Escobar, Yael-Natalie, Nedrud, Joshua, Pappas, Christopher T., Harris, Samantha P., Granzier, Henk

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2016

Language:

english

File:

PDF, 1.74 MB

english, 2016

23

Alternative Splicing of Titin Restores Diastolic Function in a HFpEF-like Genetic Murine Model (T tn ΔIAjxn )

Bull, Mathew, Methawasin, Mei, Strom, Joshua, Nair, Pooja, Hutchinson, Kirk, Granzier, Henk L

Journal:

Circulation Research

Year:

2016

Language:

english

File:

PDF, 2.49 MB

english, 2016

24

Experimentally Increasing Titin's Compliance Through RBM20 Inhibition Improves Diastolic Function in a Mouse Model of HFpEF

Methawasin, Mei, Strom, Joshua G., Slater, Rebecca E., Fernandez, Vanessa, Saripalli, Chandra, Granzier, Henk L.

Journal:

Year:

2016

Language:

english

File:

PDF, 3.91 MB

english, 2016

25

Response by Methawasin and Granzier to Letter Regarding Article, “Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Fraction”

Methawasin, Mei, Granzier, Henk

Journal:

Year:

2017

Language:

english

File:

PDF, 118 KB

english, 2017

26

Sarcomere Lengthdependent Effects on the Ca 2+ -Troponin Regulation in Skinned Myocardial Fiber from Titin RBM20 Deletion Mice

Li, King-Lun, Methawasin, Mei, Granzier, Henk, John Solaro, Ross, Tanner, Bertrand, Dong, Wen-Ji

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 45 KB

english, 2017

27

The giant protein titin regulates the length of the striated muscle thick filament

Tonino, Paola, Kiss, Balazs, Strom, Josh, Methawasin, Mei, Smith, John E., Kolb, Justin, Labeit, Siegfried, Granzier, Henk

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 1.25 MB

english, 2017

28

Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm20ΔRRM Mice

Pulcastro, Hannah C., Awinda, Peter O., Methawasin, Mei, Granzier, Henk, Dong, Wenji, Tanner, Bertrand C. W.

Journal:

Frontiers in Physiology

Year:

2016

Language:

english

File:

PDF, 4.25 MB

english, 2016

29

The Giant Protein Titin Regulates the Length of the Striated Muscle Thick Filament-Titin Rules

Granzier, Henk, Tonino, Paola, Kiss, Balazs, Strom, Joshua, Smith, John, Methawasin, Mei, Kolb, Justin

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 41 KB

english, 2018

30

Softening the Stressed Giant Titin in Diabetes Mellitus

Methawasin, Mei, Granzier, Henk

Journal:

Circulation Research

Year:

2018

File:

PDF, 47 KB

2018

31

Softening the Stressed Giant Titin in Diabetes Mellitus

Methawasin, Mei, Granzier, Henk

Journal:

Circulation Research

Year:

2018

Language:

english

File:

PDF, 47 KB

english, 2018

32

Sarcomere length–dependent effects on Ca 2+ -troponin regulation in myocardium expressing compliant titin

Li, King-Lun, Methawasin, Mei, Tanner, Bertrand C.W., Granzier, Henk L., Solaro, R. John, Dong, Wen-Ji

Journal:

The Journal of General Physiology

Year:

2018

Language:

english

File:

PDF, 1.39 MB

english, 2018

33

Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

Slater, Rebecca E., Strom, Joshua G., Methawasin, Mei, Liss, Martin, Gotthardt, Michael, Sweitzer, Nancy, Granzier, Henk L.

Journal:

The Journal of General Physiology

Year:

2018

Language:

english

File:

PDF, 1.44 MB

english, 2018

34

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

Radke, Michael H., Polack, Christopher, Methawasin, Mei, Fink, Claudia, Granzier, Henk L., Gotthardt, Michael

Journal:

Year:

2019

Language:

english

File:

PDF, 3.18 MB

english, 2019

35

Phosphodiesterase 9a Inhibition in Mouse Models of Diastolic Dysfunction

Methawasin, Mei, Strom, Joshua, Borkowski, Tomasz, Hourani, Zaynab, Runyan, Ray, Smith, John E., Granzier, Henk

Journal:

Circulation Heart Failure

Year:

2020

File:

PDF, 3.15 MB

2020